[teknomage1]

I like to use nested lists for this sort of thing.
So you have an unorderd list of unordered lists that each contain an image a desciption and whatever else you want. You can set up the inner list class to render horizontally.

Of course, the more cynical might state that that's a table and you could just make each div contain a table and use the CSS for style not layout (since the data itself is semantically tabular, it shouldn't set off the anti-table nazis).